A Closer Look at the Botox-in-a-Bottle Trend on TikTok

In recent years, TikTok has become a one-stop shop for what’s “in” when it comes to beauty TikTok has widely become known as an incubator of DIY skincare and beauty trends, such as the trend of treating acne scars with salt water, an inexpensive home treatment that many young... | Read More

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Botox in a bottleIn recent years, TikTok has become a one-stop shop for what’s “in” when it comes to beauty. TikTok has widely become known as an incubator of DIY skincare and beauty trends, such as the trend of treating acne scars with salt water, an inexpensive home treatment that many young users were quick to hop on, or cinnamon oil lip fillers, which sparked a debate among beauty influencers and dermatologists about their safety.

It’s no surprise that with thousands of videos posted every day, more and more trends are finding their way onto people’s phones and into their daily routines. One of the latest viral beauty hacks – dubbed “Botox in a bottle” – seems to offer an affordable solution to fine lines and wrinkles without the need for in-office injectables.

Under the hashtag #botoxinabottle, this new fad of mixing two high-octane skincare serums has already received more than 16 million views globally. Users who have tried the mixture claim these two products deliver effects similar to Botox: smooth, glowing skin and minimize fine lines and wrinkles. The products are Argireline Solution 10% and Matrixyl 10% + HA by the functional beauty brand, The Ordinary. Priced at just $16, they are a fraction of the price of a Botox injection, which costs $15.00 per unit at minimum.

The Botox-in-a-Bottle trend gained attention when beauty content creator Sarah Palmyra claimed she discovered a mixture that successfully smoothed the wrinkles between her eyebrows after just one month of daily use. Dermatologists quickly picked up on the trend after more and more young women on TikTok began buying the two products and making their own blend to see the results for themselves. It was very effective for certain people, leading to the question of whether it could replace Botox treatments.

How Botox-in-a-Bottle Works

Botox-in-a-Bottle works by applying a few drops of Argireline Solution 10% to the skin twice daily, then layering it with Matrixyl 10% + HA High Strength Peptide Formulation. When used daily, the effects resemble the results of Botox treatment, hence the term “Topical Botox.”

Both products are a clear, white liquid with a watery consistency easily absorbed by the skin without leaving a sticky consistency.

The main ingredient in Argireline is acetyl hexapeptide-3, a type of peptide that targets neuromuscular junctions to relax the muscles in the face. In studies, Argireline has been shown to increase collagen production and reduce the depth of wrinkles. It works similar to Botox, blocking the communication between a nerve and a muscle to reduce the movements of that muscle.

Most skin care experts agree that unlike Botox, which penetrates the targeted facial muscle, the serum cannot penetrate deep enough into the skin to have a long-lasting effect. Still, those who have seen this trend online are enthusiastically testing the serum to see if they can achieve the desired youthful effects.

@sarahpalmyra Reply to @e.michele7 #botox #beforeandafter #skincarehack #antiaging #tutorials #theordinary ♬ Spongebob Tomfoolery – Dante9k Remix – David Snell

How Topical Treatments Compare to Botox

There are some inconsistencies in the results of the Botox-in-a-bottle trend. Some of those who have tried it for themselves found the topical treatment does not freeze the muscle movement of their skin, while others have reported the disappearance of forehead and smile lines with consistent daily use.

The way I see it, the effects of this treatment are probably modest at best, a decent but temporary option for those who do not want to try injectables, do not like needles, cannot afford Botox at this time, or are not sure they want to get it yet and want to have a feel for what it would look and feel like.

If you ask me, is it ultimately worth giving this TikTok trend a chance? In my opinion, it’s convenient and affordable. If your skin is sensitive and can’t tolerate harsh anti-aging serums like retinol or other acids, these products are worth a try.

Many other products act like Botox-in-a-bottle. They exfoliate the skin, stimulate cell turnover, increase collagen and elastin production. Other skincare products, such as hydrating moisturizers and physical sunscreens also contribute to the overall well-being of the skin to achieve a younger and healthier glow. But as with any skincare routine, it’s important to find the right product appropriate for you and your skin to use consistently for optimal results.

What Results Can I Expect from Botox vs Argireline – “Topical Botox”?


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The time period in which results are visible differs between Botox injectable treatment and the use of topical Argireline and Matrixyl.

Botox treatment uses a fine needle to inject small amounts of diluted Botox® into specific targeted muscles. This may be a specific area of the face or multiple problem areas. Botox treatment is relatively quick with little to no discomfort. The results of Botox injections are visible as early as 4-5 days after treatment and full results take up to a full 2 weeks. While its effects may wear off after 4-6 months, it is recommended to maintain the treatment consistently to benefit its long-term benefits.

Argireline and Matrixyl results, on the other hand, take much longer and results vary. You will need to apply the serums daily and keep track of whether your skin responds, as irritation can occur. Botox-in-a-bottle takes longer to show, and the results aren’t as effective and long-lasting.

If you would like to try Botox treatments to effectively eliminate fine lines and wrinkles, The Memorial Spa in Houston, TX, provides complimentary consultations. In addition, Botox is also effective in treating certain medical conditions, such as muscle discomfort, excessive sweating, migraines, urinary bladder control, lazy eye, eye twitching, or blepharospasm.

As experts in non-invasive cosmetic procedures, our team will help you find the appropriate treatment to prevent and treat signs of aging like sun damage and wrinkles so you can look and feel your best. Call The Memorial Spa at 713-633-4411 to schedule a consultation with us today or to learn more about Botox.

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*This blog is created and maintained for informational purposes only. The images present may not accurately reflect actual cases per individual. Individual cases are unique, and the descriptions and solutions will vary per patient.

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